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Metabolix, Inc. Files Registration Statement for Proposed Initial Public Offering of Common Stock

July 17, 2006

Cambridge, MA. Metabolix, Inc. announced today that it has filed a registration statement with the Securities and Exchange Commission for the initial public offering of its common stock.  Piper Jaffray & Co. will be the sole book-running manager for the offering.  Jefferies & Company, Inc., Thomas Weisel Partners LLC and Ardour Capital Investments, LLC will be co-managers for the offering.

A registration statement relating to these securities has been filed with the Securities and Exchange Commission but has not yet become effective. These securities may not be sold nor may offers to buy be accepted prior to the time that the registration statement becomes effective. This news release shall not constitute an offer to sell or the solicitation of an offer to buy nor shall there be any sale of these securities in any state or jurisdiction in which such offer, solicitation, or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction. The offering will be made only by means of a prospectus. When available, copies of the preliminary prospectus relating to this offering may be obtained from Piper Jaffray & Co., 800 Nicollet Mall, Suite 800, Minneapolis, MN 55402.

About Metabolix
Metabolix is a biotechnology company that develops and plans to commercialize environmentally sustainable, economically attractive alternatives to petrochemical-based plastics, fuels and chemicals. For more information, please visit www.metabolix.com.

Contact information:

James J. Barber
President & CEO
(617) 492-0505 x225
barber@metabolix.com

Thomas G. Auchincloss
Chief Financial Officer
(617) 492-0505 x221
auchincloss@metabolix.com
www.metabolix.com